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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: Two cases with a different outcome.

Navarro JT, Feliu E, Grau J, Espinet B, Colomer D, Ribera JM, Oriol A, Granada I, Juncà J, Millá F

Servei d'Hematologia, Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Badalona.

Chromosomal abnormalities in Ph-negative metaphases from patients with chronic myeloid leukemia (CML) treated with imatinib have been described in some cases. Trisomy 8 is the most frequent, but monosomy 7 has also been described. However, the association of these chromosomal alterations with myelodysplasia has been scarcely reported. We report the appearance of monosomy 7 in Ph-negative cells, associated with severe dysplasia, in two patients with CML treated with imatinib, with a different outcome: one with a transient evolution and the other evolving to acute myeloid leukemia. Am. J. Hematol., 2007. (c) 2007 Wiley-Liss, Inc.

Published 13 August 2007 in Am J Hematol, 82(9): 849-51.
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