Glivec Research Today is a free monthly online journal that collates and summarizes the latest research about Glivec, including details on gleevec, imatinib, cancer, treatment, side-effects.

Treatment of wild-type gastrointestinal stromal tumor (WT-GIST) with imatinib and sunitinib.

Murray M, Hatcher H, Jessop F, Williams D, Carroll N, Bulusu R, Judson I

Oncology Department, Addenbrooke's Hospital, Cambridge, UK. mjm16@cam.ac.uk

We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib.

Published 12 December 2007 in Pediatr Blood Cancer, 50(2): 386-8.
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